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Does MMV effect on the antioxidative defense system? Further investigation is needed to provide more insight to the mechanisms of MMV-mediated brain function improvement in neurodegeneration. Thirunavukkarasu Research officer cum Chief Radio Chemist, Medical Cyclotron Facility Dr.Aluminium concentration was altered essential trace elements of CNS and increased susceptibility of CNS to lipid peroxidation and induces oxidative stress of neuronal damage for formation of ROS [8,9].The previous studies observed that act as a potential effect against Al induced free radical generation of oxidative stress protein (HSP70) involved neuronal damage of nerve cells evidenced by histological studies [10]. [11] confirmed that Al causes considerable damage of cerebral function include learning memory impairment in rats was linked to develop Alzheimer’s disease (AD) [12,13].Apoptotic, anti-apoptotic genes such as Bcl-2, Bcl-x L and caspas-3 were estimated by Western blot and Reverse transcriptase polymerase chain reaction (RT- PCR).In these results clearly observed that MMV treatment was markedly increased 5-HT and restrain cognitive functions as well as decreased expression of pro-apoptotic genes against Al induced animals .Targets of redox signaling induced by metals has been suggested to be potential therapeutic interventions in metal-induced toxicity and carcinogenesis.Aluminum is a known risk factor for neurodegeneration such as those in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

[2] reported aluminum and its salts extensively damaged nervous system and impaired learning and memory of rats.

Aluminum and its salts extensively damaged nervous system and impaired learning and memory animals in neurodegenerative disease.

In this study were conducted five groups, six animals in each group.

It activates neurotoxicity in central nervous, skeletal and hematopoietic systems [4].

The extensive damage of nervous system caused learning and memory impairment of animals.

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